France History Essay Example | Topics and Well Written Essays - 1000 words

France History - Essay Example He goes further to explain how the French revolution and Haitian revolution; influenced the eradication of slavery through enactment of new laws. His claim is valid, as well as the rationale she provides in establishing his argument. In the essay, the writer has outlined the positive effects brought about by French revolution and Haiti revolution. As a way of illustrating, he argued that the French revolution has inspired the American Revolution. In addition, he has stated how declaration of freedom was written. It resulted into freedom from slavery in both Haiti and France. In my opinion, these illustrations were explained properly. Furthermore, the writers attempt to explain the hierarchy of leadership and challenges affecting the two countries; creates a clear impression. From my point of view, discrimination of slaves as being less human is ruthless. It goes a long way to affecting social aspects of an individual. In conclusion, the writer’s argument was expressed clearly. However, the points offered were less. As stated before, the revolution of France was more important in terms of enacting new enlightenment principles; is certainly true. In my opinion, the argument was not properly covered; there was a need for more supportive points. There was need to include extra materials on the related topic; this meant to play a significant role in shedding more light. Moreover, it would provide more points necessary in supporting the thesis statement. There are many sources of information regarding revolution of France and Haiti; although, my focus will be limited to sources with great depth of information. To start with, A Concise History of The Haitian Revolution provides a clear overview of the revolution in Haiti. It elaborates on the impacts of the revolution (Popkin 22). Secondly, The French Revolution of 1789 And Its Impact provides information about the factors that led to the revolution and its effects (Rubenstein 82). Finally, Haitian

The Energy Problem Essay Example | Topics and Well Written Essays - 1000 words

The Energy Problem - Essay Example "We think that the recent run-up in gasoline prices has significantly increased the likelihood that we will see another gas crisis in the near future. This is regardless of whether there is a true shortage, or if it's just panic buying that takes hold. Don't be surprised to see gasoline rationing being put in place as soon as this occurs, whether it is imposed by the retailers, or by the government. Don't be surprised to see long lines at the pumps, a la 1972." (The Coming Gasoline Crisis). This paper will deal with the gasoline crisis and it will compare the cost of production of Gasoline to Ethanol in order to suggest a solution to this problem. The conclusion will sum up the major points of the paper. "In 2003, the U.S. Department of Agriculture surveyed 21 dry-mill ethanol plants to estimate their 2002 production costs, including both variable (feedstock and plant operation) and capital expenses. These plants produced about 550 million gallons of ethanol in 2002. Net feedstock costs for the surveyed plants ranged from 39 to 68 cents per gallon in 2002. For cash operating expenses, the average energy expenditure was 17.29 cents per gallon. Labor costs ranged from 3 to 11 cents per gallon, maintenance costs from 1 to 7 cents, and administrative costs from 1 to 18 cents. For capital expenditures, new plant construction costs from $1.05 to $3.00 per gallon of ethanol." (Ethanol). There has been a significant rise in the production of Ethanol over the years, the facts speak for themselves and it is found that only 200 million gallons were produced in the year 1980, on the other hand the year 2004 saw a high increase in this figure, it was found that 200 million of Ethanol was produced during the year, the same also gave rise to the no of Ethanol plants. Way back in 1980s Ethanol was only produced as a fuel meant to extend the supply of gasoline. "In 2004, more than 80 percent of the ethanol produced was used in State oxygen-mandated markets and in a winter-oxygenated program. The rest was used to enhance the octane rating in gasoline throughout the United States. Ethanol production has also been boosted by improved technologies for growing corn, a major input; corn yields increased an average of 40 percent per acre from 1979-81 to 2002-04." (Ethanol). When the operational cost of Ethanol is taken into account, it basically involves two factors, namely capital costs and variable costs. Some of the components which come under variable costs include electricity, water etc. This is called variable cost because it never remains constant, the price keeps varying. As far as the largest operating expenses are concerned, it was found that in the year 2002 on an average 17.29 cents per gallon of ethanol was produced, which is way too high. In the Capital costs segment it was found that "For new plants, construction costs ranged from $1.05 to $3.00 per gallon of ethanol. The average cost of building new plants is lower than in the past, possibly due to designs that exploit economies of scale. Of the 21 plants responding to the survey, 16 increased their capacity in 2002 by a combined 253 million gallons per year. Average investment to expand

Leadership Talents of Jack Welch Essay Example for Free

Leadership Talents of Jack Welch Essay Jack Welch was a successful Chief Executive Officer (CEO) of General Electric Co. (GE) for twenty years (1981 – 2001). He was admired and feared for the â€Å"new vision† that was implemented at GE. Jacks talented strategies were based on how he saw the hierarchy layers of management, how he analyzed the 42 strategic business units, and how he implemented the culture of GE to have the feel and the passion that he had been striving for. These strategies received a lot of positive and negative attention and as a result the company’s value increased by 4,000% during his tenure at GE. Jack Welch was born John Francis Welch, Jr. on November 19, 1935. He earned a Bachelor of Science degree in chemical engineering from the University of Massachusetts in 1957. Then he went on to earn a M.S. and Ph.D. in chemical engineering from the University of Illinois in 1960. He was introduced to Carolyn Osburn through a mutual friend, and then approximately six months later they were engaged. By November, 1959 they married two days after Welch’s 24th birthday. In 1960, Dr. Dan Fox offered Welch a chemical engineering position to work on a new project on a new thermoplastic called polyphenylene oxide (PPO) at GE. PPO was described to withstand high temperatures, which could replace hot water copper piping and stainless-steel medical instruments. Welch realized after his first year at GE that he disliked GE’s bureaucracy, which nearly drove him to leave based on the standard predetermined $1,000 raise he received in 1961. He was fed up and walked up to his boss Burt Coplan and quit. Coplan’s boss, Reuben Gutoff (Reg) called Welch and offered to meet for dinner. Gutoff took Carolyn and Jack out for dinner and promised a bigger raise, more responsibility, and would keep the bureaucracy out of his way. In addition, Gutoff added another $2,000 raise on top of the $1,000 raise Coplan already given him, which showed Welch he was serious about his promise. In 1972, Jack was named the company’s youngest Vice President then was elected Vice Chairman in 1979, then was elected the eighth chairman and Chief Executive Officer (CEO) in 1981. Jack held this position until he retired in 2001. During his twenty year term as CEO Jacks reputation In 1999, Forbes magazine named him â€Å"Manager of the Century† and the Financial Times named him one of the three most admired business leaders in the world today (General Electric Company). During Jacks twenty year tenure at GE he was able to step outside of the box and change the way the game was played. (Business Pundit, 2008).

Structure And Properties Of Ibuprofen

Structure And Properties Of Ibuprofen Ibuprofen, which is a member of the propionic acid group of Non-steroidal anti-inflammatory, drugs (NSAIDs). Ibuprofen is a racemic mixture of [+]S- and [-]R-enantiomers. Ibuprofen contains contains a stereocenter in the ÃŽ ±-position of the  propionate  moiety. Studies shown that [+]S -ibuprofen was the active form and it showed activity in both in-vivo and in-vitro. Ibuprofen is white to off-white in colour and occurs as a crystalline powder, with a melting point of 74 ° to 77 °C. It is practically insoluble in water, but readily soluble in organic solvents such as ethanol and acetone. Ibuprofen has a pKa value of 4.43 ±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is ( ±)-2-(p-iso-butylphenyl) propionic acid. The molecular weight of ibuprofen is 206.28. Its molecular formula is C13H1802. Mechanism of action The major action of Ibuprofen and all other Non-steroidal anti-inflammatory drugs and is the inhibition of the cyclooxygenase enzyme or the COX enzymes and hence inhibiting the synthesis of prostaglandins. These cyclooxygenase enzymes catalyse the reaction of synthesis of prostaglandins and thromboxanes from arachidonic acid, which in turn is synthesized from phospholipids by the action of the phospholipase enzyme. The prostaglandins and thromboxanes are then responsible for the synthesis of various inflammatory mediators. There are two types of cyclooxygenase enzymes namely, cyclooxygenase enzyme-I (COX-I) and cyclooxygenase enzyme-II (COX-II). COX-I is a constitutive enzyme which is released in most of the body tissues including the blood platelets. COX-I performs a house-keeping role in the body and is involved in the tissue homeostasis. Whereas, COX-II is present in the inflammatory cells and is responsible for the production of prostanoid mediators, which are responsible for inf lammation, pain and fever. Therefore, inhibition of the COX-II leads to the anti-inflammatory, anti-pyretic and analgesic activity of ibuprofen and whereas on the other hand, inhibition of COX-II is responsible for the unwanted effects of ibuprofen in the gastric mucosa and on platelet aggregation. In 2002, a study reported that, ibuprofen selectively inhibits a new variant  of the  COX enzyme that was totally different  from the  then known two variants of cyclooxygenase enzymes, the COX-I and  COX-II. This iso-enzyme is now referred as the COX-III enzyme. Study also showed that this COX-III enzyme was only expressed in the  brain and  in the  spinal cord. Its exact  mechanism  and actions is still poorly understood, but future research  may provide  further insight into how it works. A study on rats has shown that administration of ibuprofen increases the  bioavailability of serotonin (5-HT) in rats and evidence for a similar mechanism  in humans was also found. Chronic ibuprofen doses in rat showed down-regulation of central 5-HT2A receptors and  an increase  in the  number of serotonin transporter proteins. In 2006, a study showed that ibuprofen is converted to N-arachidonoyl phenolamine, or AM404, a compound known as an endogenous cannabinoid reuptake inhibitor and it indirectly activates the  CB-I cannabinoid receptor, resulting  in analgesia. This activity was proven through the  induction of a CB-I receptor antagonist  which  resulted in the  reversal of the  analgesic action  of ibuprofen. Pharmacokinetics Absorption Ibuprofen is well absorbed from the gastro intestinal tract. The peak plasma level of ibuprofen is reached within 1 to 2 hours. It was shown in a study that absorption of ibuprofen is faster in fasting conditions. Food affects the rate of absorption of ibuprofen but the extent of absorption remains unchanged. The study also showed that, ibuprofen when administered with food delays the time taken for peak plasma concentration by approximately 30-60 minutes. Distribution Ibuprofen like the other agents of its class is highly protein bound. It was found in a study that about 90-99% of ibuprofen was protein bound at a concentration of 20 µg/ml and this binding was non-linear. The volume of distribution ibuprofen changes with age and fever conditions. Studies reveal that febrile childrens less than 11 years old have volume of distribution approximately 0.2 L/kg, while adults have volume of distribution approximately 0.12 L/kg. Metabolism Ibuprofen is extensively metabolised in the liver to form inactive metabolic compounds. Ibuprofen is mainly metabolised by glucoronidation reaction. A study showed that majority of the ibuprofen dose was recovered in the urine as hydroxy phenyl propionic acid (25%) and carboxy propyl phenyl propionic acid (37%) metabolites. Elimination Ibuprofen and its inactive metabolites are rapidly and completely excreted by the kidney. About 95% of the administered dose of ibuprofen is eliminated in the urine. The elimination half-life of ibuprofen is in the range of 1.9 hours to 2 hours. Pharmacological activity Ibuprofen has the following pharmacological actions on the biological system Antipyretic effect Analgesic effect Anti-inflammatory effect Antipyretic effect A normal body temperature is regulated by a centre in the hypothalamus that ensures a balance between heat loss and heat production in the body. Therefore, the hypothalamus maintains a normal temperature of the body and thus it acts as a thermostat. When there is a disturbance in this hypothalamic thermostat, temperature of the body set by the hypothalamus is raised, fever occurs. Ibuprofen and other Non-steroidal anti-inflammatory drugs reset this rise in the temperature. It regulates various temperature regulatory mechanisms such as dilation of superficial blood vessels, sweating etc. to reduce the temperature. Ibuprofen and other NSAIDs do not affect the normal temperature. Ibuprofen and other NSAIDs are thought to act as antipyretic agents by inhibiting the prostaglandin production in the hypothalamus. During an inflammatory reaction, the bacterial endotoxins cause a release of a pyrogen-IL-1 from macrophages. This release of pyrogen stimulates the generation of E-type prostaglandins in the hypothalamus, this in turn causes the elevation of temperature. There are evidences that prostaglandins are not the only mediators of fever, hence ibuprofen and other NSAIDs may have some alternate mechanisms for their antipyretic activity which is not yet known. Analgesic effect Ibuprofen is mainly effective against pain associated with inflammation or tissue damage. This is due to the inhibition of prostaglandins that sensitise nociceptors to inflammatory mediators such as bradykinin. Therefore ibuprofen is effective against pains that are associated with increased prostaglandin synthesis. Their ability to relieve headache may be related to the inhibition of the vasodilator effect of prostaglandins on the cerebral vasculature. There are some evidences that ibuprofen have a central effect by an action mainly in the spinal cord where it inhibits the COX-III enzyme. This action of ibuprofen is not yet clearly known. Anti-inflammatory activity Many chemical mediators are released when there is a stimulus of an inflammatory and allergic response. This response leads to vasodilation, increased vascular permeability, cell accumulation, etc., which are produced by several mechanisms. Furthermore, different mediators may be of particular importance in different inflammatory and allergic conditions. Ibuprofen reduces mainly those components of the inflammatory and immune response in which mediators produced by COX-II enzyme action plays a significant part. The components inhibited by ibuprofen are vasodilation, oedema and pain. Ibuprofen has no effect on those processes which contribute to tissue damage as in chronic inflammatory conditions such as rheumatoid arthritis, vasculitis and nephritis. Uses of ibuprofen Ibuprofen is used to treat a wide range of illnesses such as headaches, backache, menstrual cramps, dental pain, neuralgia, rheumatic pain, muscular pain, migraine, arthritis and athletic injuries. Ibuprofen is also used to reduce fever and to relieve minor aches and pain caused due to common cold or flu.   In a recent study, it was found that ibuprofen was effective in the treatment of Alzheimers disease when given in low doses over a long period of time. A study also showed that ibuprofen is associated with a lower risk of Parkinsons disease, and ibuprofen may help in delaying and prevent it. . Adverse effects of Ibuprofen Ibuprofen appears to have  the  lowest  incidence of adverse  drug  reactions  (ADRs)  when compared to all other  non-selective  NSAIDs. However, this only holds  true  at lower doses of ibuprofen. Common adverse  effects of ibuprofen with the gastrointestinal tract include nausea, dyspepsia, heartburn, gastrointestinal ulceration and bleeding, diarrhoea, loss of appetite, stomach pain. Effects on central nervous system include headache, dizziness, fatigue and nervousness. Hypersensitivity reactions include skin rashes, itching. In very rare cases ex-foliative dermatitis and epidermal necrolysis has been observed. Infrequent  adverse  effect includes- oesophageal ulceration, heart failure, hyperkalaemia, renal impairment, confusion,  bronchospasm, and  salt and  fluid retention [11] Photosensitivity Like the other agents of the NSAIDs,  ibuprofen has also been reported to be  a photosensitising  agent.[12][13]  However, this only rarely occurs with ibuprofen and  it is considered to be  a very weak photosensitising  agent  when compared with other members of Non-steroidal anti-inflammatory drugs. This is because the  ibuprofen molecule contains  only a single phenyl moiety and  no  bond  conjugation,  resulting  in a very weak chromophore system and  a very weak absorption spectrum  which  does not reach  into the  solar spectrum. Cardiovascular risk Ibuprofen has been reported to elevate the  risk  of myocardial infarction,  particularly among  those taking chronically  high  doses of ibuprofen [14] Risk in pregnancy Studies have  found an increased risk  of miscarriage  with the  use of ibuprofen in early pregnancy; however, there are no thorough findings in  this association.  There are also  concerns  that drugs such  as ibuprofen may interfere with implantation of the  early foetus, although a clear risk has not been established. When ibuprofen is used as directed in the  first  and  second trimester of pregnancy,  it is not associated with an increased risk  for birth defects. However, ibuprofen is generally not used  during  pregnancy because there are concerns  with their  use during  the  third trimester. Ibuprofen Overdose Ibuprofen is the most commonly and widely used Non-steroidal anti-inflammatory agent all over the world. Since, ibuprofen was licensed as an over the counter drug, ibuprofen overdose became a common phenomenon. The most common symptoms of ibuprofen overdose are unsteadiness, blurred vision, ringing in the ears, gastrointestinal, nausea plus vomiting, diarrhoea, stomach pain, probable loss of blood in intestinal areas or stomach or both, headache, agitation, drowsiness, incoherence and confusion etc. Sometimes more serious symptoms are also noticed in some victims, such as seizure, gastrointestinal bleeding, metabolic acidosis, respiratory depression, hyperkalaemia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, renal failure, cyanosis, and cardiac arrest etc., however these symptoms are very rare. The  severity of symptoms varies with the ingested dose  and  the  time elapsed. However, individual sensitivity also plays  an important  role. Generally,  the  symptoms observed with an overdose  of ibuprofen are similar to the  symptoms caused by  an overdose of other NSAIDs. Doses of ibuprofen below 100 mg/kg are less likely to produce any toxic effects. But doses of ibuprofen above 400 mg/kg are considered an overdose and can result into any of the above consequences.

Free Yellow Wallpaper Essays: Descriptions :: Yellow Wallpaper essays

Descriptions The Yellow Wallpaper The descriptive elements in The Yellow Wallpaper do a tremendous amount towards enhancing the reader's perception of the particular kind of insanity that afflicts the narrator. The descriptions, most notably of the wallpaper itself, are multi-sensory, artful and detailed. Using metaphorical images, and surprising combinations of words, the narrator gives numerous ways for readers to experience the wallpaper. In the line regarding the wallpaper: "...they connect diagonaly, and the sprawling outlines run off in great slanting waves of optic horror, like a lot of wallowing seaweeds in full chase." The word pairings of 'optic horror' and the similie are unusual and sensory. This serves to peak the reader's interest and more effectively draw the reader into the description. Additionally, the range of descriptions of the wallpaper not only cover several intense and detailed visual descriptions, but also an equally detailed olfactory description. The narrator describes the smell of the wallpaper in the following lines: But there is something else about that paper - the smell! I noticed it the moment we came into the room, but with so much air and sun it was not bad. Now we have had a week of fog and rain, and whether the windows are open or not, the smell is here. It creeps all over the house. I find it hovering in the dining-room, skulking in the parlor, hinding in the hall, lying in wait for me on the stairs. It gets into my hair. Even when I go to ride, if I turn my head suddenly and surprise it-there is that smell! Such a peculiar odor, too! I have spent hours trying to analize it, to find what it smelled like. It is not bad - at first, very gentle, but quite the subtlest, most enduring odor I ever met. In this damp weather it is awful. I wake up in the night and find it hanging over me. It used to disturb me at first. I thought seriously of burning the house-to reach the smell. But now I am used to it. The only thing I can think of that it is like is the color of the paper! A yellow smell. The two most notable descriptions of the wallpaper also follow (paragraphs removed to save space): I never saw a worse paper in my life.

Death of a Salesman :: essays papers

Drug For Sanity in Death of a Salesman Willy Lowman’s Drug for Sanity No one’s life can be classified as â€Å"normal†. Everyone has conflicts that they have to eventually deal with. People do in fact deal with these personal conflicts in different ways; some take it easy some take it hard. Some ignore the problem as long as possible and some deal with it right away to get it out of the way. In Death of a Salesman, Willy Lowman’s technique to his problem solving leads to severe consequences. Willy never does anything to help the situation; he just escapes into the past to happier times when there were few problems. He uses this escape as if it was a drug, and as the play goes on, this drug becomes dangerous, leading him to his death. The first time Willy is seen dazing off into the past is when he discovers Biff arriving home. The conversation between Willy and Linda reflects Willy’s disappointment in Biff and what Willy thinks he has become basically a bum. After failing to deal with his feelings, he escapes to a time when things were better for his family. It is not uncommon for one to think of better times at low points in their life in order to cheer them up so that they are able to deal with problems, but Willy Lowman takes it a step ahead. His stubbornness to accept reality is so strong that in his mind he is placed back in time to relive one of the happier days of his life. It was a time when no one argued. Willy and Linda were younger, the financial situation was less of a burden, and Biff and Happy welcomed their father back home from being on a long work trip. Willy’s need for the â€Å"drug† reassures himself that everything will turn out okay and that his family will be happy once again like it was in the past. The next flashback occurs during a discussion between Willy and Linda. Willy is depressed about his inability to make enough money to support his family, his looks, and his personality. â€Å" My God if business doesn’t pick up, I don’t know what I am going to do!†(1808) is what Willy said after Linda figures out that they are in fact in debt. Then he blurts out without letting any reply to his comment, â€Å"I’m Fat. Death of a Salesman :: essays papers Drug For Sanity in Death of a Salesman Willy Lowman’s Drug for Sanity No one’s life can be classified as â€Å"normal†. Everyone has conflicts that they have to eventually deal with. People do in fact deal with these personal conflicts in different ways; some take it easy some take it hard. Some ignore the problem as long as possible and some deal with it right away to get it out of the way. In Death of a Salesman, Willy Lowman’s technique to his problem solving leads to severe consequences. Willy never does anything to help the situation; he just escapes into the past to happier times when there were few problems. He uses this escape as if it was a drug, and as the play goes on, this drug becomes dangerous, leading him to his death. The first time Willy is seen dazing off into the past is when he discovers Biff arriving home. The conversation between Willy and Linda reflects Willy’s disappointment in Biff and what Willy thinks he has become basically a bum. After failing to deal with his feelings, he escapes to a time when things were better for his family. It is not uncommon for one to think of better times at low points in their life in order to cheer them up so that they are able to deal with problems, but Willy Lowman takes it a step ahead. His stubbornness to accept reality is so strong that in his mind he is placed back in time to relive one of the happier days of his life. It was a time when no one argued. Willy and Linda were younger, the financial situation was less of a burden, and Biff and Happy welcomed their father back home from being on a long work trip. Willy’s need for the â€Å"drug† reassures himself that everything will turn out okay and that his family will be happy once again like it was in the past. The next flashback occurs during a discussion between Willy and Linda. Willy is depressed about his inability to make enough money to support his family, his looks, and his personality. â€Å" My God if business doesn’t pick up, I don’t know what I am going to do!†(1808) is what Willy said after Linda figures out that they are in fact in debt. Then he blurts out without letting any reply to his comment, â€Å"I’m Fat.

King Lear and Gloucester: Mirror Images Essay

King Lear tells of an old, senile ruler who, having given up his title, divides his land between his two villainous daughters, and his third daughter is exiled. Parallel to Lears situation is the sub-plot of Gloucester, whose bastard son betrays him and his legitimate son Edgar. Shakespeare undoubtedly intended for the characters of Gloucester and King Lear to mirror each other, and by comparing them and their outcomes me can see how closely related they truly are. Both King Lear and Gloucester are quick to anger, and thus their favoured children are quickly dismissed. Lear rashly decides to split up his land according to which daughters flatter him most. Cordelia tells her father she loves him according to [her] bond; no more nor less(I.i.l 92), angering the foolish King, who has her exiled to France. Gloucester is also hasty in writing off his son Edgar, from whom Edmund forges a letter stating he wants his father dead so he can have his land. Both characters are quick to anger, and quick to act, later lamenting the decisions they made. Gloucester and Lear both make impetuous decisions regarding their children, being blind to the treachery of others. Lear is blind to the malice of Goneril and Regan: They say they love him, merely to get his land. They even lock him out of Gloucesters castle during a storm. Like Lear, Gloucester instantly believes the letter he is shown, being blind to the lies Edmund tells about Edgar. Edmund further manipulates the situation, betraying his father, and consequently Gloucester has his eyes ripped out. When Lear comes upon him, Gloucester being then literally blind, he astutely observes that a man may see how [the] world goes with no eyes(IV.vi.ll.146-47). Luckily for Gloucester, he is recovered by Edgar, who bec[omes] his guidesav[ing] him from despair, using various disguises. This is echoed by Cordelia, who comes to England with the French army to recover Lear from his mad wanderings in the countryside. Cordelia does save her father, just as Edgar defends his father from Oswald. Both characters are rescued by their favoured children, though later they both die. It is clear that many similarities exist between Gloucester and King Lear,  not only in character, but in their actions and outcomes. By taking a look at how the two characters are alike in King Lear, we may also further appreciate their differences. Bibliography: King Lear, by William Shakespeare